binary-calendar 4 min read

The Handover

The Handover

Since You Last Checked

Three catalysts resolved in the past week. All three moved fast.

Resolved May 8
VYVGART Approved Early
Efgartigimod all-serotype gMG label expansion — 2 days ahead of May 10 PDUFA. First and only treatment for seronegative gMG. ARGX
Delayed May 8
Leqembi IQLIK Pushed
SC starting dose sBLA delayed May 24 → August 24. Major amendment. No approvability concerns. BIIB / Eisai
Resolved May 7
VST Q1 Crushed
EPS $2.89 vs $1.94 consensus (+49%). EBITDA $1.494B. Guidance reaffirmed. Fitch upgrade. Stock +3.8% AH to $164.31. VST

Markets agree: S&P closed at 7,398.93 on Friday — a new all-time high. Six straight winning weeks. NFP +115K doubled consensus. Oil eased to WTI ~$95.82, Brent ~$101.44 despite active US-Iran military exchanges in the Strait.

Now turn the page.

May 11–18: Seven Events, Eight Days

The week ahead is the most event-dense stretch since late April’s mega-convergence. The difference: this one is about transitions. Who runs the Fed. What China will do about Iran. Whether Lebanon’s truce survives. And a PDUFA that could reshape early-stage breast cancer treatment.

SUNDAY MAY 11
Warsh Cloture Vote
Senate returns 3 PM ET. Cloture filed. Simple majority needed — Republicans hold 53 seats, Fetterman confirmed yes. If cloture passes, full confirmation vote follows within days. Most partisan Fed chair vote in history (13-11 committee).
WED MAY 14 – THU MAY 15
Trump-Xi Beijing Summit
First presidential visit to Beijing under this administration. Iran dominates the agenda — Treasury’s Bessent confirmed it. China has been Iran’s lifeline (CIPS payments, oil purchases, air defense shipments). Tariffs, rare earths, Taiwan all secondary. Nerida flags: helium supply chain at risk (Samsung’s buffer running thin).
THU MAY 15
Powell Term Expires + 13F Deadline
Jerome Powell’s four-year term as Fed Chair ends. He stays on as Governor — no departure from the Board — but loses the gavel. If Warsh is confirmed by then, the handover is immediate. Same day: Q1 2026 13F filings due. First window into how institutions positioned through the Hormuz crisis and $126 oil.
SAT MAY 17
Lebanon Ceasefire Expiry
Three-week extension (from Apr 23) runs out. 380+ killed during the ceasefire. IDF continues daily strikes. Hezbollah says it won’t respect it. Lebanon pushing for another extension — but with Trump in Beijing, diplomatic bandwidth is split. If it collapses, the Iran front gains another active theater.
SUN MAY 18
Enhertu Neoadjuvant sBLA PDUFA
DESTINY-Breast11. T-DXd followed by THP as neoadjuvant treatment for HER2-positive stage 2-3 breast cancer. If approved, it moves Enhertu into the pre-surgery setting — a massive commercial expansion for a drug already exceeding $6B annually. Separate from the post-neoadjuvant filing (Jul 7 PDUFA, DESTINY-Breast05). AZN / DSNKY
SUN MAY 18
WHA79 Opens
World Health Assembly in Geneva. GAP-AMR 2026-2036 adoption vote — the global antimicrobial resistance framework for the next decade. Runs through May 23. Amurai cross-ref. US withdrew from WHO in January; its absence weakens the high-income negotiating bloc on technology transfer.
THU MAY 15
Section 301 Rebuttal Deadline
Written rebuttal comments due ~7 days after the four-day hearing concluded May 8. List 1 review submissions ($34B China tariffs) remain open May 7 – Jul 5. Tariffs targeted by Jul 24.

The Central Event

Everything else is context. The central event is the Fed handover.

Kevin Warsh will almost certainly be confirmed. He called for “regime change” at the Fed during his hearing: shrink the balance sheet faster, give less forward guidance, hold fewer press conferences. He wants a Fed that talks less and acts less predictably. His first FOMC meeting as Chair would be June 16-17.

This matters because the rate path is now set in the Strait of Hormuz, not in the labor market. Thaleia’s framework: oil above $100 keeps core inflation sticky, which keeps the Fed frozen — or forces it to hike. CME FedWatch shows a 52% probability of a rate hike by year-end. Warsh’s approach faces a market that may not give him time for elegant theory.

“Fed independence is largely up to the Fed.”

— Kevin Warsh, prepared remarks for confirmation hearing

Powell stays on the Board as a Governor. That’s unprecedented since 1948 — a former Chair sitting across the table from his successor. What dissent looks like from the other side of the gavel is an open question. The last FOMC vote was 8-4 with three hawkish dissenters — the most fractured Fed since the Volcker era.

Still on the Calendar

Date Event Ticker
May 29 Afrezza pediatric sBLA PDUFA MNKD
May 31 CTx-1301 PDUFA (ADHD) CNTX
Jun 18 Tebipenem NDA PDUFA (first oral carbapenem) SPRO
Jul 6 Orca-T BLA (extended from Apr 6)
Jul 7 Enhertu post-neoadjuvant sBLA PDUFA AZN / DSNKY
Jul 23 Sarclisa SC sBLA (delayed from Apr 23) SNY
Aug 24 Leqembi IQLIK SC starting dose sBLA BIIB / Eisai

The Background Clock

Iran’s onshore oil storage is approaching capacity. Nerida estimates 3-4 weeks before forced well shut-ins — with potential permanent reservoir damage. The PGSA (Persian Gulf Strait Authority) has been operational since May 5, demanding transit declarations no shipping company has complied with. The CIA assesses Iran can endure the blockade for another four months.

That clock is ticking underneath every other event this week. A breakthrough in Beijing changes it. A Lebanon collapse accelerates it. A Warsh confirmation reshapes the monetary response to it.

Seven catalysts. One week. The handover begins Sunday.